Increased Activation of the TRESK K+ Mediates Vago-Vagal Reflex Malfunction in Diabetic Rats.

@article{Grabauskas2016IncreasedAO,
  title={Increased Activation of the TRESK K+ Mediates Vago-Vagal Reflex Malfunction in Diabetic Rats.},
  author={Gintautas Grabauskas and Xiaoyin Wu and Il Han Song and S Y Zhou and Thomas M Lanigan and Chung Owyang},
  journal={Gastroenterology},
  year={2016},
  volume={151 5},
  pages={
          910-922.e7
        }
}
BACKGROUND & AIMS Patients with diabetes have defects in the vagal afferent pathway that result in abnormal gastrointestinal function. We investigated whether selective increased activation of the 2-pore domain potassium channel TRESK (2-pore-domain weak inward-rectifying potassium channel-related spinal cord potassium channel) contributes to nodose ganglia (NG) malfunction, disrupting gastrointestinal function in diabetic rats. METHODS We conducted whole-cell current-clamp and single-unit… CONTINUE READING
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