Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1 receptor.

@article{Lee2007IncreasedAT,
  title={Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1 receptor.},
  author={Y K Lee and In-Kyung Song and Kyung-Jin Jang and Jakob Nielsen and J\orgen Fr\okiaer and S\oren Nors Nielsen and T Kwon},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={292 1},
  pages={F340-50}
}
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two peptide hormones (Am J Physiol Renal Physiol 288: F673-F684, 2005). To directly address this issue, primary cultured inner medullary collecting duct (IMCD) cells from male Sprague-Dawley rats were treated for 15 min with 1) vehicle… CONTINUE READING