Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells

@article{Daschner1999IncreasedAA,
  title={Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells},
  author={Phillip J. Daschner and Henry P. Ciolino and Cathie A. Plouzek and Grace Chao Yeh},
  journal={Breast Cancer Research and Treatment},
  year={1999},
  volume={53},
  pages={229-240}
}
The expression, DNA binding, and transactivating activity of activator protein 1 (AP-1) was examined in a series of multidrug resistant (MDR) MCF-7 human breast cancer cells that have increasing levels of MDR1 gene expression. We observed an increase in the amount of both c-jun and c-fos mRNA in cells with 12-, 65-, or 200-fold higher resistance to adriamycin when compared to drug-sensitive MCF-7 wild type (WT) cells. Electrophoretic mobility shift assays (EMSA) demonstrated an increase in the… CONTINUE READING

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