Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo.

@article{Okuno1999Increased9A,
  title={Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-beta mediated fibrogenesis in vivo.},
  author={Masataka Okuno and Takashi Sato and Takuya Kitamoto and Shosuke Imai and Norifumi Kawada and Yasuhiro Suzuki and Hitoshi Yoshimura and Hisataka Moriwaki and Kaori Onuki and Shoichi Masushige and Yasutoshi Muto and Scott L Friedman and Satomi Kato and Soichi Kojima},
  journal={Journal of hepatology},
  year={1999},
  volume={30 6},
  pages={1073-80}
}
BACKGROUND/AIMS During hepatic fibrosis, hepatic stellate cells (HSCs) transform into myofibroblastic cells and lose their intracellular droplets of retinyl esters, the storage form of vitamin A. Recently, we have demonstrated that 9,13-di-cis-retinoic acid (RA), a geometric isomer identified as a stable and major metabolite of vitamin A in circulation, stimulates the synthesis of plasminogen activator (PA) and induces PA/plasmin-dependent latent transforming growth factor (TGF)-beta activation… CONTINUE READING
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