Increased 8-hydroxydeoxyguanosine in high-grade gliomas is associated with activation of autophagy.

@article{Lian2014Increased8I,
  title={Increased 8-hydroxydeoxyguanosine in high-grade gliomas is associated with activation of autophagy.},
  author={Minxue Lian and Xiaodong Zhang and Hui Wang and Hao Liu and Wei Chen and Shiwen Guo},
  journal={The International journal of neuroscience},
  year={2014},
  volume={124 12},
  pages={926-34}
}
AIM OF THE STUDY To understand the interaction between oxidative stress and autophagy in gliomas of different grades. MATERIALS AND METHODS In the present study, we analyzed levels of oxidative stress in 45 human glioma tumors, using the DNA oxidation marker 8-hydroxydeoxyguanosine (8-OHdG). In addition, we determined activation of autophagy in gliomas samples by assessing expression of microtubule-associated protein 1 light chain-3B (LC3B). To confirm our in vivo findings, in vitro studies… CONTINUE READING