Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation.

@article{Chanplakorn2011Increased5T,
  title={Increased 5α-reductase type 2 expression in human breast carcinoma following aromatase inhibitor therapy: the correlation with decreased tumor cell proliferation.},
  author={Niramol Chanplakorn and Pongsthorn Chanplakorn and Takashi Suzuki and Katsuhiko Ono and Lin Wang and Monica Sze Man Chan and Loo Wing and Christopher C P Yiu and Louis Wing-Cheong Chow and Hironobu Sasano},
  journal={Hormones & cancer},
  year={2011},
  volume={2 1},
  pages={73-81}
}
Tumor cell proliferation and progression of breast cancer are influenced by female sex steroids. However, not all breast cancer patients respond to aromatase inhibitors (AI), and many patients become unresponsive or relapse. Recent studies demonstrate that not only estrogens but also androgens may serve as regulators of estrogen-responsive as well as estrogen-unresponsive human breast cancers. However, the mechanism underlying these androgenic actions has remained relatively unknown. Therefore… CONTINUE READING

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