Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

@article{Schoch2016Increased4I,
  title={Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model},
  author={Kathleen M. Schoch and Sarah L DeVos and Rebecca L Miller and Seung Jong Chun and Michaela Norrbom and David F. Wozniak and Hana N. Dawson and C. F. Bennett and Frank W Rigo and Timothy M. Miller},
  journal={Neuron},
  year={2016},
  volume={90},
  pages={941-947}
}
Pathological evidence for selective four-repeat (4R) tau deposition in certain dementias and exon 10-positioned MAPT mutations together suggest a 4R-specific role in causing disease. However, direct assessments of 4R toxicity have not yet been accomplished in vivo. Increasing 4R-tau expression without change to total tau in human tau-expressing mice induced more severe seizures and nesting behavior abnormality, increased tau phosphorylation, and produced a shift toward oligomeric tau. Exon 10… CONTINUE READING
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