Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.

@article{Ferrante1997Increased3A,
  title={Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.},
  author={Robert Ferrante and Leslie A. Shinobu and J{\"o}rg Bernhard Schulz and Russell Thomas Matthews and Clare E. Thomas and Neil W. Kowall and Mark E Gurney and Myron Flint Beal},
  journal={Annals of neurology},
  year={1997},
  volume={42 3},
  pages={326-34}
}
Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS). Transgenic mice that express these point mutations develop progressive paralysis and motor neuron loss thought to be caused by a gain-of-function of the enzyme. The gain-of-function may be an enhanced ability of the mutant SOD1 to generate .OH radicals or to facilitate peroxynitrite-mediated nitration of proteins. We found significant increases in… CONTINUE READING