Corpus ID: 231697417

Increased [

  title={Increased [},
  author={Y. Shimizu and Yukihiro Nakai and H. Watanabe and Shimpei Iikuni and Masahiro Ono and H. Saji and Y. Kuge and T. Saga and Y. Nakamoto},
  • Y. Shimizu, Yukihiro Nakai, +6 authors Y. Nakamoto
  • Published 2021
  • Background: [F]Fluoromisonidazole ([F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypoxic cells. In addition, we found that the [F]FMISO uptake level varied depending on the cellular glutathione conjugation and excretion ability such as enzyme activity of glutathione-S-transferase and expression levels of multidrug resistance-associated protein 1 (MRP1, an efflux… CONTINUE READING
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