Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation.

@article{Ishimori2002IncreasedU,
  title={Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation.},
  author={Takayoshi Ishimori and Tsuneo Saga and Marcelo H. Mamede and Hisataka Kobayashi and Tatsuya Higashi and Yuji Nakamoto and Noriko Sato and J. Konishi},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2002},
  volume={43 5},
  pages={658-63}
}
UNLABELLED The aim of this project was to study a mechanism that might explain the increased uptake of (18)F-labeled FDG seen in inflammation. The approach chosen was to examine the effect on (18)F-FDG uptake of acute activation of murine lymphocytes by concanavalin A (Con A). METHODS Immunocompetent BALB/c mice and nude mice received an intravenous injection of 10 mg/kg Con A. Twenty-four hours later, the mice received an intravenous injection of 0.74 MBq (20 microCi) (18)F-FDG. One hour… CONTINUE READING

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