Increased &ggr;-Aminobutyric Acid Levels in Mouse Brain Induce Loss of Righting Reflex, but Not Immobility, in Response to Noxious Stimulation

@article{Katayama2007IncreasedA,
  title={Increased \&ggr;-Aminobutyric Acid Levels in Mouse Brain Induce Loss of Righting Reflex, but Not Immobility, in Response to Noxious Stimulation},
  author={Sohtaro Katayama and Masahiro Irifune and Nobuhito Kikuchi and Tohru Takarada and Yoshitaka Shimizu and Chie Endo and Takashi Takata and Toshihiro Dohi and Tomoaki Sato and Michio Kawahara},
  journal={Anesthesia \& Analgesia},
  year={2007},
  volume={104},
  pages={1422-1429}
}
BACKGROUND:The general anesthetic state comprises behavioral and perceptual components, including amnesia, unconsciousness, and immobility. &ggr;-Aminobutyric acidergic (GABAergic) inhibitory neurotransmission is an important target for anesthetic action at the in vitro cellular level. In vivo, however, the functional relevance of enhancing GABAergic neurotransmission in mediating essential components of the general anesthetic state is unknown. Gabaculine is a GABA-transaminase inhibitor that… Expand
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