Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake.

@article{Joy2008IncreaseOU,
  title={Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake.},
  author={Tisha R. Joy and Grace Walsh and Sonya Tokmakejian and Stan Van Uum},
  journal={Canadian journal of gastroenterology = Journal canadien de gastroenterologie},
  year={2008},
  volume={22 1},
  pages={
          49-53
        }
}
  • T. Joy, Grace Walsh, +1 author S. Van Uum
  • Published 2008
  • Medicine
  • Canadian journal of gastroenterology = Journal canadien de gastroenterologie
BACKGROUND 5-hydroxyindoleacetic acid (5-HIAA) excretion is commonly measured for biochemical detection of carcinoid tumours. A 77-year-old woman was referred for elevated 24 h urine 5-HIAA excretion (510 micromol/day; normal is less than 45 micromol/day) and serum chromogranin A (CgA) (72.1 U/L; normal is less than 18 U/L), both subsequently normalized after discontinuation of 5-hydroxytryptophan (5-HTP). 5-HTP, a precursor of serotonin, is not commonly listed as a substance that increases 5… Expand
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TLDR
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TLDR
To determine whether measurement of serotonin in urine would give useful complementary information to the usual measurement of 5-hydroxyindoleacetic acid (5-HIAA) in urine and platelet serotonin in platelets, I measured these analytes in 75 consecutive patients with carcinoid tumors and found that measurement of urinary serotonin excretion is helpful in the evaluation of patients with suspected carcinoid tumor. Expand
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  • Chemistry, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 1976
TLDR
The time course of plasma 5-hydroxyindoles after oral administration of 5-Hydroxytryptophan is studied in two subjects as an example of the application of the method and of its possible role in monitoring the plasma levels in therapy or in provocative tests. Expand
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