Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin.

Abstract

In this study, doxorubicin (DOX)-loaded long circulating liposomes combined with curcumin (CUR) (DOX-CUR-LCLs) were successfully prepared as a novel formulation for cancer treatment. The particle size and distribution, zeta potential, drug loading capacity, and entrapment efficiency (EE) of the preparation were characterized. The in vitro anti-tumor activities of DOX-CUR-LCLs and DOX-LCLs against A549 cells were then evaluated and compared with that of free DOX. Cytotoxicity evaluation showed that DOX-CUR-LCLs had a significantly higher antitumor activity than other DOX preparations. These results suggest that novel DOX-CUR-LCLs, combination of DOX and CUR administered in long-circulating liposomes, could improve antitumor activity.

Cite this paper

@article{Wang2011IncreaseOT, title={Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin.}, author={Hong Wang and Liandong Hu and Chunlei Li and Jingguo Zhang and Tao Zhang}, journal={Die Pharmazie}, year={2011}, volume={66 11}, pages={871-4} }