Increase of sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites.

@article{Morimoto1980IncreaseOS,
  title={Increase of sister chromatid exchanges and perturbations of cell division kinetics in human lymphocytes by benzene metabolites.},
  author={Kanehisa Morimoto and Sheldon Wolff},
  journal={Cancer research},
  year={1980},
  volume={40 4},
  pages={1189-93}
}
Benzene, which has been associated with human cancers, is metabolized to produce several major metabolites that could be responsible for the biological effects. Tests have now been carried out on human lymphocytes in culture to determine if benzene or its metabolites, phenol, catechol, and hydroquinone, induce cytogenetic changes and affect the cell cycle. The results indicate that benzene itself does not induce sister chromatid exchanges or affect cell cycle kinetics over a wide range of doses… CONTINUE READING
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