Increase of sensitivity and uptake of vinblastine by reserpine in rat ascites hepatoma.


We investigated the effect of reserpine on the antitumor effect of vinblastine (VBL) with regard to the drug resistance of rat ascites hepatomas. The sensitivity to VBL was in the order of AH13 greater than AH44 greater than AH109A greater than AH66 cells in the in vitro growth-inhibitory test, and AH66 cells were inherently most resistant to VBL. The… (More)


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