Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease

  title={Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease},
  author={Amanda Fortes Francisco and Paula Melo de Abreu Vieira and Jerusa Marilda Arantes and Ma{\'i}sa Silva and Maria L{\'u}cia Pedrosa and Silvana Maria El{\'o}i-Santos and Olindo Assis Martins-Filho and Andr{\'e}a Teixeira-Carvalho and M{\'a}rcio Sobreira Silva Ara{\'u}jo and Washington Luiz Tafuri and Cl{\'a}udia Martins Carneiro},
  booktitle={Redox report : communications in free radical research},
Oxidative stress is common in inflammatory processes associated with many diseases including Chagas' disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant system in order to provide an overview of the mechanism of action of the iron chelator desferrioxamine (DFO). The study population comprised 48 male Swiss mice, half of which were treated daily by intraperitoneal injection of DFO over a 35-day… CONTINUE READING


Publications referenced by this paper.

Oxidative stress in chronic cardiopathy associated with Chagas’ disease

TB De Oliveira, RC Pedrosa, D. Wilhelm Filho
  • Int J Cardiol
  • 2007

Secondary iron overload.

  • Hematology. American Society of Hematology. Education Program
  • 2001