Increase of proteinuria after conversion from calcineurin inhibitor to sirolimus-based treatment in kidney transplant patients with chronic allograft dysfunction.

@article{Ruiz2006IncreaseOP,
  title={Increase of proteinuria after conversion from calcineurin inhibitor to sirolimus-based treatment in kidney transplant patients with chronic allograft dysfunction.},
  author={Juan C Ruiz and Josep Mar{\'i}a Campistol and Ana Isabel S{\'a}nchez-Fructuoso and Constantino Rivera and Juan Oliver and D. Ramos and Bego{\~n}a Campos and Manuel Arias and F. Diekmann},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2006},
  volume={21 11},
  pages={3252-7}
}
BACKGROUND Conversion from calcineurin inhibitor to sirolimus, rapamycin has become an option in patients with chronic allograft dysfunction (CAD). However, in many cases an increase of proteinuria has been observed. The aim was to characterize the course of this so far unexplained proteinuria after conversion. METHODS In 149 renal transplant patients from various Spanish centres, proteinuria and renal function were analysed 6 months before until 6 months after conversion. Patients were… CONTINUE READING

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