Increase of ocular blood flow by some phytogenic compounds.

@article{Liu1996IncreaseOO,
  title={Increase of ocular blood flow by some phytogenic compounds.},
  author={Sherry Xueyu Liu and Chiao-hsi Chiang and Q S Yao and George C. Y. Chiou},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  year={1996},
  volume={12 2},
  pages={
          95-101
        }
}
  • S. Liu, C. Chiang, +1 author G. Chiou
  • Published 1996
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
The effects of a number of phytogenic compounds on ocular blood flow were measured by the colored microsphere technique in rabbits. Methyltyramine and coumarin increased blood flow in all eye tissues tested. The blood flow of iris, ciliary body-iris root, retina and choroid was increased by methyltyramine for 255%, 322%, 189%, and 189%, respectively, and by coumarin for 375%, 193%, 139% and 299%, respectively, at 120 minutes after drug administration. Rescinnamine, apocynin and hesperetin also… Expand
Structure-activity relationship (SAR) between some natural flavonoids and ocular blood flow in the rabbit.
  • Young-Hyun Park, G. Chiou
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2004
TLDR
The ocular blood flow is increased significantly by the number of OH group in the molecule, with three the best to increase the ocularBlood flow. Expand
Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes.
  • Young-Hyun Park, Xin-rong Xu, G. Chiou
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2004
TLDR
The presence of OH groups at certain positions and the double bond at C2-C3 in the flavonoid molecules, which produces lipophilic action, can affect the increment on ocular blood flow and retinal function recovery. Expand
Effects of dihydrogenation of flavones and number of hydroxy groups in the molecules on ocular blood flow in rabbits and retinal function recovery in rats.
  • Xin-rong Xu, Young-Hyun Park, G. Chiou
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2004
TLDR
Results indicate that hydrogenation is an excellent way to convert natural flavones into more potent compounds of flavanones. Expand
Effects of C-nitropyrazoles and C-nitroazoles on ocular blood flow and retinal function recovery after ischemic insult.
TLDR
C-Nitropyrazoles can facilitate significant retinal function recovery after ischemic insult through the increase of ocular blood flow through the decrease of C-nitropyrazole among all 17 compounds studied. Expand
Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat.
  • G. Chiou, Xin-rong Xu
  • Chemistry, Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 2004
TLDR
Naringenin, hesperetin, and rutin were found to produce marked positive effects on b-wave recovery, whereas naringin, hesperid in, and quercetin showed poor recovery of b- wave after ischemic insult of the retina. Expand
Effects of Chinese herbal products on mammalian retinal functions.
  • S. Liu, G. Chiou
  • Medicine
  • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
  • 1996
TLDR
Natural products isolated from Chinese herbs for improving ocular blood flow and inflammation, and natural products which can improve retinal functions measured with electroretinogram's b-wave recovery are reviewed. Expand
Improvement of ocular blood flow and retinal functions with puerarin analogs.
TLDR
Puerarin and all its derivatives, except ET (puerarin disubstituted with -CH2CH2OH), showed marked increase of choroidal blood flow at various time periods, indicating that puerarin analogs could be used for the treatment of ischemic retinopathy, and AMD in particular. Expand
Effects of crocin analogs on ocular blood flow and retinal function.
TLDR
Results indicated that crocin analogs could be used to treat ischemic retinopathy and/or age-related macular degeneration and it was noted that disaccharide analogs of crocin, such as crocin-1 andCrocin-2, were less potent than monosaccharides of croin, constituting an interesting structure-activity relationship. Expand
Effects of N-nitropyrazoles on ocular blood flow of rabbits and retinal function recovery of rat eyes after ischemic insults.
TLDR
The structure activity relationship of the N-nitropyrazoles to increase ocular blood flow and to facilitate retinal function recovery after ischemic insults were discussed. Expand
Oral consumption of α-glucosyl-hesperidin could prevent lens hardening, which causes presbyopia
TLDR
G-Hsd represents the first oral treatment agent with anti-presbyopia and/or anti-cataract properties and upregulated the mRNA expression of anti-oxidative enzymes in the plasma and lens, and prevented prematureCataract symptoms in selenite-induced cataract rat lens. Expand
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