Increase of metaiodobenzylguanidine uptake and intracellular half-life during differentiation of human neuroblastoma cells.

@article{Montaldo1996IncreaseOM,
  title={Increase of metaiodobenzylguanidine uptake and intracellular half-life during differentiation of human neuroblastoma cells.},
  author={Paolo Giuseppe Montaldo and Lizzia Raffaghello and Francesco Guarnaccia and Vito Pistoia and Alberto Garaventa and Maurilio Ponzoni},
  journal={International journal of cancer},
  year={1996},
  volume={67 1},
  pages={95-100}
}
Iodine-labelled metaiodobenzylguanidine (MIBG) is a radiopharmaceutical used for diagnostic imaging and targeted radiotherapy of neuroendocrine tumors. We previously reported that the ability of a neuroblastoma (NB) cell line, LAN-5, to accumulate MIBG was powerfully stimulated by interferon-gamma (IFN-gamma), a well-known NB differentiation-promoting agent. To extend the above findings, we have investigated 5 NB cell lines for their ability to accumulate 125I-MIBG in basal conditions or after… CONTINUE READING