Increase of histaminergic tuberomammillary neurons in narcolepsy.

@article{Valko2013IncreaseOH,
  title={Increase of histaminergic tuberomammillary neurons in narcolepsy.},
  author={Philipp O Valko and Yury V. Gavrilov and Mihoko Yamamoto and Hasini Reddy and Johannes Haybaeck and Emmanuel Mignot and Christian R. Baumann and Thomas E Scammell},
  journal={Annals of neurology},
  year={2013},
  volume={74 6},
  pages={
          794-804
        }
}
OBJECTIVE Narcolepsy is caused by loss of the hypothalamic neurons producing the orexin/hypocretin neuropeptides. One key target of the orexin system is the histaminergic neurons of the tuberomammillary nucleus (TMN), an essential wake-promoting system. As cerebrospinal fluid histamine levels may be low in patients with narcolepsy, we examined histaminergic neurons in patients with narcolepsy and in 2 mouse models of narcolepsy. METHODS We counted the number of hypothalamic neurons producing… CONTINUE READING
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