Increase of glomerular filtration rate and renal plasma flow by insulin-like growth factor-I during euglycaemic clamping in anaesthetized rats.

@article{Baumann1992IncreaseOG,
  title={Increase of glomerular filtration rate and renal plasma flow by insulin-like growth factor-I during euglycaemic clamping in anaesthetized rats.},
  author={U Baumann and Th. Eisenhauer and Helmut Hartmann},
  journal={European journal of clinical investigation},
  year={1992},
  volume={22 3},
  pages={204-9}
}
Renal function was studied in anaesthetized rats receiving i.v. infusions of recombinant human insulin-like growth factor-I (IGF-I) under euglycaemic clamp conditions. IGF-I increased glomerular filtration rate up to 35% and renal plasma flow up to 100%, this increase being dose dependent with half-maximal stimulation at serum IGF-I concentrations of about 24 pmol ml-1. Renal vascular resistance was reduced up to 50%, filtration fraction decreased up to 30% and urine flow increased up to three… CONTINUE READING

From This Paper

Topics from this paper.
8 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…