Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion

@article{Kossmehl2005IncreaseOF,
  title={Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion},
  author={Peter Walter Kossmehl and Johann Sch{\"o}nberger and Mehdi Shakibaei and Shideh Faramarzi and E J Kurth and Britta Habighorst and R{\"u}diger Bauer and Markus Wehland and Reinhold Kreutz and Manfred Infanger and Gundula Gesine Schulze-Tanzil and Martin Paul and Daniela Grimm},
  journal={Journal of Molecular Medicine},
  year={2005},
  volume={83},
  pages={626-637}
}
Following a severe ischemic injury or myocardial infarction, the extracellular matrix (ECM) of the heart is involved in pathophysiological conditions such as dilatation and cardiac dysfunction. Osteopontin (OPN) has been shown to interact with fibronectin suggesting its possible role in matrix organization, stability and wound healing. There is increased expression of OPN in several tissues in response to injury. Therefore, we tested the hypothesis that acute ischemia (2 h), followed by… 
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