Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation

@article{Sousa1996IncreaseOC,
  title={Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation},
  author={G{\'e}ssica Sena de Sousa and Sophie A Langou{\"e}t and Françoise Nicolas and Giocondo Lorenzon and Michel Placidi and Rahmatollah Rahmani and Andr{\'e} Guillouzo},
  journal={Cell Biology and Toxicology},
  year={1996},
  volume={12},
  pages={351-358}
}
The study was designed to investigate the effects of phenobarbital (PB), 3-methylcholanthrene (3-MC), and oltipraz (OPZ), a synthetic derivative of 1,2-dithiole-3-thione, on the levels of cytochrome P450 1A1/2 and gluthathione transferase (GST) mRNAs in both fresh and cryopreserved human, monkey, and dog hepatocytes in primary culture. GST α mRNAs were demonstrated in liver parenchymal cells from the three species: after 4 days of culture, their basal levels were decreased, but were strongly… CONTINUE READING
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