Increase of cholesterol level in the surface membrane of lymphoma cells and its inhibitory effect on ascites tumor development.

@article{Inbar1974IncreaseOC,
  title={Increase of cholesterol level in the surface membrane of lymphoma cells and its inhibitory effect on ascites tumor development.},
  author={Michael Inbar and Meir Shinitzky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1974},
  volume={71 5},
  pages={2128-30}
}
An ascites form of malignant transformed lymphoma cells were treated in vitro with liposomes of 1:1 lecithin-cholesterol in order to increase the cholesterol level of the cell-surface membranes and thereby to increase the rigidity of the lipid layer. This treatment was found to inhibit the rate of killing by ascites tumor after intraperitoneal inoculation into adult mice of 10(4) and 10(5) treated cells per animal. With 10(3) treated cells per animal, full survival was observed up to 90 days… CONTINUE READING

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