Increase of Urokinase-type Plasminogen Activator Gene Expression in Human Lung and Breast Carcinomas 1

  • Andre-Pascal, Sappine, +4 authors Vassalli
  • Published 2006


To assess the postulated correlation between plasminogen activators (PAs) and malignancy, we determined the mRNA content for urokinasetype (u-PA) and tissue-type (t-PA) enzymes in a prospective series of 29 primary lung and 27 primary breast carcinomas. Dot blots of total RNAs were hybridized with appropriate cRNA probes under conditions that allow… (More)

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