Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.

@article{Mori2017IncreaseOT,
  title={Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy.},
  author={Keita Mori and Hideki Yokoi and Masato Kasahara and Hirotaka Imamaki and Akira Ishii and Takashige Kuwabara and Kenichi Koga and Yukiko Kato and Naohiro Toda and Shoko Ohno and Koichiro Kuwahara and Tomomi Endo and Kazuwa Nakao and Motoko Yanagita and Masashi Mukoyama and Kiyoshi Mori},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2017},
  volume={28 1},
  pages={
          278-289
        }
}
The amount of albumin filtered through the glomeruli and reabsorbed at the proximal tubules in normal and in diabetic kidneys is debated. The megalin/cubilin complex mediates protein reabsorption, but genetic knockout of megalin is perinatally lethal. To overcome current technical problems, we generated a drug-inducible megalin-knockout mouse line, megalin(lox/lox);Ndrg1-CreERT2 (iMegKO), in which megalin expression can be shut off at any time by administration of tamoxifen (Tam). Tam… CONTINUE READING
Tweets
This paper has been referenced on Twitter 12 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Similar Papers

Loading similar papers…