Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA.

@article{Schuchardt2014IncreaseOE,
  title={Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA.},
  author={Jan Philipp Schuchardt and Inga L Schneider and I. M. Willenberg and Jun Yang and Bruce D Hammock and Andreas Hahn and Nils Helge Schebb},
  journal={Prostaglandins & other lipid mediators},
  year={2014},
  volume={109-111},
  pages={23-31}
}
INTRODUCTION Several supplementation studies with long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) describe an increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acids in blood, while changes in levels of other LC n-3 and n-6 PUFA-derived oxylipins were minor. In order to investigate the kinetics of changes in oxylipin levels in response to LC n-3 PUFA ingestion, we conducted a single dose treatment study with healthy subjects. SUBJECTS AND METHODS In the present kinetic… CONTINUE READING
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