Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production.

@article{Lavie2007IncreaseOB,
  title={Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production.},
  author={Fr{\'e}d{\'e}ric Lavie and Corinne Miceli-Richard and Marc Ittah and J{\'e}r{\'e}mie Sellam and J E Gottenberg and Xavier Mariette},
  journal={Annals of the rheumatic diseases},
  year={2007},
  volume={66 5},
  pages={700-3}
}
BACKGROUND The cytokine B cell-activating factor of the TNF family (BAFF) is involved in the pathogenesis of autoimmune diseases. OBJECTIVE To access changes in serum protein and mRNA levels of BAFF after rituximab treatment. METHODS Serum and peripheral blood mononuclear cells (PBMCs) were isolated from five patients (two with lupus, two with Sjögren's syndrome, one with rheumatoid arthritis) before and 12 weeks (range 7-17) after a first course of rituximab infusion. Monocytes and B cells… CONTINUE READING

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