Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients.

@article{Isobe2009IncreaseIT,
  title={Increase in the oxidized/total coenzyme Q-10 ratio in the cerebrospinal fluid of Alzheimer's disease patients.},
  author={Chiaki Isobe and Takashi Abe and Yasuo Terayama},
  journal={Dementia and geriatric cognitive disorders},
  year={2009},
  volume={28 5},
  pages={449-54}
}
BACKGROUND/AIM The contribution of mitochondrial dysfunction and oxidative stress to the pathogenesis of Alzheimer's disease (AD) has previously been described. We aimed to investigate whether the balance between the oxidized and reduced forms of coenzyme Q-10 (CoQ-10) is related to the pathogenesis of AD. MATERIALS AND METHOD Thirty patients with AD (69.0 +/- 4.1 years) and 30 healthy control subjects (63.8 +/- 16.4 years) were enrolled in this study. Concentrations of oxidized CoQ-10 and… CONTINUE READING

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