Increase in the effectiveness of melphalan therapy with progression of MOPC-315 plasmacytoma tumor growth

Abstract

Following inoculation with 1×106 MOPC-315 tumor cells, a single injection of a very low dose of melphalan (l-PAM, l-phenylalanine mustard), 0.75 mg/kg, cured most of the mice bearing a day 11 large primary tumor (20 mm) and metastases, but failed to cure mice bearing a day 4 nonpalpable tumor. Treatment of mice bearing a nonpalpable tumor with the very low… (More)
DOI: 10.1007/BF00199699

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