Increase in telomerase activity during progression of melanocytic cells from melanocytic naevi to malignant melanomas

Abstract

During successive cell divisions of mortal cells the length of the telomeres (TTAGGG repeats in vertebrates) at the end of chromosomes decreases. It has been suggested that this process is responsible for cellular senescence. Expression of the ribonucleoprotein telomerase appears to prevent shortening of telomeres in germ-line cells and cancer cells. The… (More)
DOI: 10.1007/s004030050387

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