Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus.

@article{Forrest2008IncreaseIS,
  title={Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus.},
  author={Abigail Forrest and Jan D. Huizinga and Xuan-Yu Wang and Louis W C Liu and Mike Parsons},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2008},
  volume={294 1},
  pages={G315-26}
}
Diabetes affects many aspects of gastrointestinal motility, in part due to changes in interstitial cells of Cajal (ICC). The effect of diabetes on the colon, however, is not well characterized, and the aim of the present study was to investigate possible relationships between altered colonic motility as a consequence of streptozotocin-induced diabetes and injury to ICC. Physiological, immunohistochemical, and ultrastructural techniques were employed. The motor pattern of the rat colon was… CONTINUE READING