Increase in somatostatin immunoreactivity in the suprachiasmatic nucleus of aged Wistar rats

@article{Biemans2002IncreaseIS,
  title={Increase in somatostatin immunoreactivity in the suprachiasmatic nucleus of aged Wistar rats},
  author={Barbara A. M Biemans and Menno P Gerkema and Eddy A. van der Zee},
  journal={Brain Research},
  year={2002},
  volume={958},
  pages={463-467}
}
Decreased immunoreactivity has been reported for several neuropeptides in the aged suprachiasmatic nucleus (SCN). We compared somatostatin (SS) and substance P (SP) immunoreactivity (ir) in aged (20-26 months) and young (6 months) Wistar rats. The old rat SCN revealed a significant increase in SSir (2.6-fold) and SPir. The results show that not all SCN-neuropeptidergic systems decline with age, and suggest a specific age-related role for SS in the SCN. 

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References

Publications referenced by this paper.
Showing 1-5 of 5 references

Neurotransmitters of the hypo - of somatostatin - immunoreactivity in the suprachiasmatic nucleus of thalamic suprachiasmatic nucleus : immunocytochemical analysis of the rat

Y. Isobe Shinohara, J. Takeuchi, S. T. Inouye, K. L. Tsujimoto van den Pol
Neurosci . Biobehav . Rev . • 1995

Co - localization of neuronal group in the rat suprachiasmatic nucleus : a double labeling preprosomatostatin mRNA and preprotachykinin A mRNA in in situ hybridization study

H. Okamura, T. Matsuda, Y. Shigeyoshi, Y. Hisa, Y. Maebayashi Shigeyoshi
Mol . Cell . Neurosci . • 1992

Immunocytochemical localization ofdegree of connectivity with other SCN neurones , sug - somatostatin - containing neurons in the rat hypothalamus , Cell gesting an important modulatory role

F. Vandesande Dierickx
In view of the Tissue Res .