Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice.

@article{Lewis2004IncreaseIS,
  title={Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice.},
  author={Katherine E. Lewis and Elizabeth A. Kirk and Thomas O. McDonald and Shari A Wang and Thomas N Wight and Kevin D O'brien and Alan Chait},
  journal={Circulation},
  year={2004},
  volume={110 5},
  pages={540-5}
}
BACKGROUND Elevated serum amyloid A (SAA) levels are associated with increased cardiovascular risk. SAA levels can be increased by dietary fat and cholesterol. Moreover, SAA can cause lipoproteins to bind extracellular vascular proteoglycans, a process that is critical in atherogenesis. Therefore, we hypothesized that diet-induced increases in SAA would increase atherosclerosis independent of their effect on plasma cholesterol levels. METHODS AND RESULTS Female LDL-receptor-null (LDLR… CONTINUE READING