Increase in secretory sphingomyelinase activity and specific ceramides in the aorta of apolipoprotein E knockout mice during aging.

@article{Kobayashi2013IncreaseIS,
  title={Increase in secretory sphingomyelinase activity and specific ceramides in the aorta of apolipoprotein E knockout mice during aging.},
  author={Keiko Kobayashi and Eri Nagata and Kazuki Sasaki and Mariko Harada-Shiba and Shosuke Kojo and Hiroe Kikuzaki},
  journal={Biological & pharmaceutical bulletin},
  year={2013},
  volume={36 7},
  pages={1192-6}
}
Atherosclerosis is caused by many factors, one of which is oxidative stress. We recently demonstrated that systemic oxidative stress increased secretory sphingomyelinase (sSMase) activity and generated ceramides in the plasma of diabetic rats. In addition, we also showed that the total ceramide level in human plasma correlated with the level of oxidized low-density lipoprotein. To investigate the relationship between ceramide species and atherogenesis during aging, we compared age-related… CONTINUE READING