Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals.

  title={Increase in pulmonary ventilation-perfusion inequality with age in healthy individuals.},
  author={J Card{\'u}s and Felip Burgos and O. Diaz and Josep Roca and Joan Albert Barber{\`a} and Ram{\'o}n Mar{\'i}a Marrades and Roberto Rodr{\'i}guez-Rois{\'i}n and Peter D. Wagner},
  journal={American journal of respiratory and critical care medicine},
  volume={156 2 Pt 1},
Arterial oxygen tension (PaO2) is known to decrease with age, and this is accompanied by a number of changes in mechanical properties of the lungs, including loss of elastic recoil and increase in closing volume. The changes in respiratory mechanics with age could induce greater ventilation/perfusion (VA/Q) mismatch and thus explain the decrease in PaO2. In 64 normal subjects aged 18 to 71 yr (lifetime nonsmokers with normal spirometry), we measured VA/Q inequality and arterial respiratory… CONTINUE READING

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