Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India

@article{Srikanth2000IncreaseIP,
  title={Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India},
  author={Padma Srikanth and R C Castillo and Gopalan Sridharan and T. Jacob John and Anand Zachariah and Dilip Mathai and David H. Schwartz},
  journal={International Journal of STD and AIDS},
  year={2000},
  volume={11},
  pages={49 - 51}
}
Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS… Expand
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