Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India

  title={Increase in plasma IL-10 levels and rapid loss of CD4+ T cells among HIV-infected individuals in south India},
  author={Padma Srikanth and R C Castillo and Gopalan Sridharan and T. Jacob John and Anand Zachariah and Dilip Mathai and David H. Schwartz},
  journal={International Journal of STD and AIDS},
  pages={49 - 51}
Increased levels of immune activation among HIV patients from developing countries are believed to accelerate and/or enhance the shift to a Th2 cytokine environment, which in turn may result in a more rapid progression to AIDS. In support of this hypothesis, we present data from a cohort of 35 HIV+ individuals in southern India. Among asymptomatic individuals in this cohort, a dramatic increase in plasma interleukin (IL)-10 coincided with rapid decrease in CD4 counts and progression to AIDS… Expand
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CD4+ lymphocyte count in African patients co-infected with HIV and tuberculosis.
  • D. Martin, J. Sim, +7 authors K. Keddy
  • Medicine
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  • 1995
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Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.
The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection. Expand
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  • 1997
revised clinical classi ® cation for HIV infection and expanded surveillance case de ® nition for AIDS among adolescents and adults