Increase in neutralizing antibody titer against sequential autologous HIV‐1 isolates after 16 weeks saquinavir (invirase) treatment

@article{Sarmati1997IncreaseIN,
  title={Increase in neutralizing antibody titer against sequential autologous HIV‐1 isolates after 16 weeks saquinavir (invirase) treatment},
  author={L. Sarmati and E. Nicastri and G. el-Sawaf and L. Ventura and A. Salanitro and L. Ercoli and S. Vella and M. Andreoni},
  journal={Journal of Medical Virology},
  year={1997},
  volume={53}
}
  • L. Sarmati, E. Nicastri, +5 authors M. Andreoni
  • Published 1997
  • Biology, Medicine
  • Journal of Medical Virology
  • The humoral immune response to HIV infection plays an important role in determining disease progression. Few and discordant results correlate changes in neutralizing antibody (NtAb) titer with antiretroviral treatment. The NtAb titer against autologous‐HIV was evaluated in 33 patients treated with the protease inhibitor saquinavir (SQV, Invirase) and zidovudine (ZDV) alone or in combination. Ten out of 33 (30%) patients showed a significant increase (4‐fold or greater) in NtAb titer from… CONTINUE READING
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