Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: a stereological study using the nucleator method.

@article{Jack1990IncreaseIH,
  title={Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: a stereological study using the nucleator method.},
  author={E M Jack and Philip Bentley and Farin H. Bieri and S. F. Muakkassah-Kelly and Willy St{\"a}ubli and Joseph J. Suter and Felix Waechter and Luis M. Cruz-Orive},
  journal={Hepatology},
  year={1990},
  volume={11 2},
  pages={286-97}
}
Gamma-glutamyltranspeptidase-positive hepatocyte foci were produced in female rats given a single dose of diethylnitrosamine neonatally after birth and, after weaning, a diet containing phenobarbitone for 30 wk. The nucleator method, a new stereological approach, provided an efficient, unbiased estimate of mean cell volume in focal lesions and extrafocal areas. It also provided an unbiased sample of cells to estimate hepatocyte nuclear volume and the percentage of binucleated cells. The results… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Comparison of mode of action of four hepatocarcinogens: a model-based approach.

Toxicological sciences : an official journal of the Society of Toxicology • 2007
View 3 Excerpts
Highly Influenced

The stem cells of the liver — a selective review

Journal of Cancer Research and Clinical Oncology • 1992
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…