Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study.

@article{Vespa1998IncreaseIE,
  title={Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study.},
  author={Paul M. Vespa and Martin Prins and Elisabeth Ronne-Engstrom and Maja J. Matari{\'c} Sven Koenig Bhaskar Krishnamachari Davi Caron and Ehud Shalmon and David A. Hovda and Neil A. Martin and Donald P. Becker},
  journal={Journal of neurosurgery},
  year={1998},
  volume={89 6},
  pages={971-82}
}
OBJECT To determine the extent and duration of change in extracellular glutamate levels after human traumatic brain injury (TBI), 17 severely brain injured adults underwent implantation of a cerebral microdialysis probe and systematic sampling was conducted for 1 to 9 days postinjury. METHODS A total of 772 hourly microdialysis samples were obtained in 17 patients (median Glasgow Coma Scale score 5+/-2.5, mean age 39.4+/-20.4 years). The mean (+/-standard deviation) glutamate levels in the… CONTINUE READING
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