Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance.

@article{Bordet2000IncreaseIE,
  title={Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharide-induced brain ischemic tolerance.},
  author={R{\'e}gis Bordet and Dominique Deplanque and Patrice Maboudou and François Puisieux and Qian Pu and Emmanuel Robin and Abraham Mart{\'i}n and M Bastide and Didier Leys and Michel Lhermitte and Bernard Dupuis},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2000},
  volume={20 8},
  pages={
          1190-6
        }
}
A low dose (0.5 mg/kg) of lipopolysaccharide (LPS), administered 72 hours before 60-minute middle cerebral artery occlusion, induced a delayed neuroprotection proven by the significant decrease (-35%) of brain infarct volume in comparison with control, whereas infarct volumes remained unchanged in rats treated 12, 24, or 168 hours before ischemia. This delayed neuroprotective effect of LPS was induced only with low doses (0.25 to 1 mg/kg), whereas this effect disappeared with a higher dose (2… CONTINUE READING
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