Increase in copy number of N-myc in retinoblastomas in comparison with chromosome abnormality.

@article{Sakai1988IncreaseIC,
  title={Increase in copy number of N-myc in retinoblastomas in comparison with chromosome abnormality.},
  author={Ken Sakai and Hiroshi Tanooka and Masao S. Sasaki and Yosuke Ejima and A. Kaneko},
  journal={Cancer genetics and cytogenetics},
  year={1988},
  volume={30 1},
  pages={119-26}
}
N-myc oncogene amplification was studied in tumor tissue DNA from Japanese retinoblastoma patients, taking into consideration their uni- or bilateral disease form, their family history, and any chromosome abnormalities. Of the 23 cases examined, seven (30%) showed a 1.9- to 2.3-fold amplification of N-myc. No correlation was found between N-myc amplification and either tumor form or family history. Two of three cases having double minute bodies in their tumors showed N-myc amplification. In two… CONTINUE READING