Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal.

  title={Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal.},
  author={L{\'i}sia von Diemen and Fl{\'a}vio Kapczinski and Anne Orgle Sordi and Joana Correa de Magalh{\~a}es Narvaez and Luciano Santos Pinto Guimar{\~a}es and F{\'e}lix Henrique Paim Kessler and Bianca Pfaffenseller and Bianca Wollenhaupt de Aguiar and Carolina de Moura Gubert and Fl{\'a}vio Pechansky},
  journal={The international journal of neuropsychopharmacology},
  volume={17 1},
Recent reports suggest that brain-derived neurotrophic factor (BDNF) could be a biomarker for relapse, drug craving and withdrawal severity. In particular, elevated BDNF levels among former cocaine users have been associated with higher rates of relapse in 90 d. However, no data are available on BDNF levels at baseline and during crack cocaine withdrawal. This study evaluated BDNF among crack cocaine users during inpatient treatment, before and after withdrawal, vs. healthy controls. Clinical… CONTINUE READING
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