Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis.

@article{Smadja2014IncreaseIB,
  title={Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis.},
  author={David M Smadja and H. V. N. Nunes and Karine Juvin and S{\'e}bastien Bertil and Dominique Valeyre and Pascale Gaussem and Dominique Israel-Biet},
  journal={Pathologie-biologie},
  year={2014},
  volume={62 6},
  pages={391-4}
}
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is associated with a marked pulmonary vascular remodeling. The aim of this study was to investigate a potential imbalance between angiogenic and angiostatic factors in this disease. METHODS AND RESULTS Sixty-four subjects with IPF and 10 healthy control subjects (60-70 years old) were prospectively included in this multicenter study. Plasma levels of vascular endothelial growth factor A (VEGF-A), thrombospondin-1 (TSP-1) and stem cell factor (SCF… CONTINUE READING