Increase in both CD14-positive and CD15-positive myeloid-derived suppressor cell subpopulations in the blood of patients with glioma but predominance of CD15-positive myeloid-derived suppressor cells in glioma tissue.

@article{Gielen2015IncreaseIB,
  title={Increase in both CD14-positive and CD15-positive myeloid-derived suppressor cell subpopulations in the blood of patients with glioma but predominance of CD15-positive myeloid-derived suppressor cells in glioma tissue.},
  author={Paul R. Gielen and Barbara M. Schulte and Esther D. Kers-Rebel and Kiek C N Verrijp and Harri{\"e}tte M J M Petersen-Baltussen and Mark ter Laan and Pieter Wesseling and Gosse J Adema},
  journal={Journal of neuropathology and experimental neurology},
  year={2015},
  volume={74 5},
  pages={390-400}
}
Myeloid-derived suppressor cells (MDSCs), defined as CD33-positive major histocompatibility complex class II-negative cells, are increased in a variety of human tumors and are associated with immunosuppression. Myeloid-derived suppressor cells can be further subdivided into CD14-positive monocytic MDSC and CD15-positive granulocytic MDSC (polymorphonuclear MDSC) subpopulations. Here we analyzed MDSC subsets in the blood and tumor tissue of patients with glioma, including the most malignant… CONTINUE READING
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