Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.

@article{Johnson2002IncreaseIB,
  title={Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.},
  author={David Robert Johnson and Sultan S. M. Habeebu and Curtis D. Klaassen},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={66 1},
  pages={16-26}
}
Glutathione (GSH) is an important cellular constituent for normal liver homeostasis. Certain drug-metabolizing enzyme inducers (i.e., phenobarbital [PB] and pregnenolone-16alpha-carbonitrile [PCN]) increase biliary excretion of GSH-derived sulfhydryls (SH) as well as bile flow, whereas other drug-metabolizing enzyme inducers (i.e., 3-methylcholanthrene [3MC… CONTINUE READING