Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus

@article{Shimazaki1994IncreaseIB,
  title={Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus},
  author={Kuniko Shimazaki and Akihiro Ishida and Nobufumi Kawai},
  journal={Neuroscience Research},
  year={1994},
  volume={20},
  pages={95-99}
}
We studied the expression of bcl-2 oncoprotein in the gerbil hippocampus after transient ischemia. Immunostaining using monoclonal antibody raised against bcl-2 oncoprotein revealed intense immunoreactivity in the CA1 area following 2 min of ischemia, which induced tolerance to subsequent ischemia and prevented delayed neuronal death (DND). Following ischemia for 5 min, however, bcl-2 oncoprotein immunoreactivity was decreased, reflecting neuronal death in the CA1 area. However, pretreatment… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 81 CITATIONS, ESTIMATED 70% COVERAGE

Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2002
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Seizure preconditioning and epileptic tolerance: models and mechanisms.

  • International journal of physiology, pathophysiology and pharmacology
  • 2009
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Activation of the nuclear factor-kappaB is a key event in brain tolerance.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2001
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1996
2018

CITATION STATISTICS

  • 5 Highly Influenced Citations