Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer.

  title={Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer.},
  author={Mark S. Talamonti and Mark S. Roh and Steven A. Curley and Gary E. Gallick},
  journal={The Journal of clinical investigation},
  volume={91 1},
Activation of the tyrosine kinase of the c-src gene product, pp60c-src, has been shown to occur in nearly every primary colorectal carcinoma, and is found as early as in polyps of high malignant potential. However, no studies have addressed potential pp60c-src changes which occur during progression. To examine this question, we have studied kinase activity and protein levels in 7 colonic polyps, 19 primary lesions, and 19 liver metastases relative to normal colonic mucosa. Significant increases… CONTINUE READING
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