Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).

@article{Lowes2005IncreaseIT,
  title={Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a).},
  author={Michelle A Lowes and Francesca N Chamian and Maria Veronica Abello and Judilyn Fuentes-Duculan and S Lin and Rachel Nussbaum and Inna Novitskaya and Henrietta Carbonaro and Irma R Cardinale and Toyoko Kikuchi and Patricia M Gilleaudeau and Mary M Sullivan-Whalen and Knut M. Wittkowski and Kim Papp and Marvin R. Garovoy and Wolfgang Dummer and Ralph Marvin Steinman and James G. Krueger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 52},
  pages={19057-62}
}
We find that CD11c(+) cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis. These CD11c(+) cells, which are evident in both epidermis and dermis, are the sites for the expression of two mediators of inflammation, inducible nitric oxide synthase (iNOS) and TNF-alpha in diseased skin. These cells express HLA-DR, CD40, and CD86, lack the Langerin and CD14 markers of Langerhans cells and monocytes, respectively, and to a significant extent express… CONTINUE READING
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