Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset

@inproceedings{RodrguezCalvo2017IncreaseIP,
  title={Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset},
  author={Teresa Rodr{\'i}guez-Calvo and Jose Zapardiel-Gonzalo and Natalie Amirian and Ericka Marie D. Castillo and Yasaman Lajevardi and Lars Krogvold and Knut Dahl-J{\o}rgensen and Matthias G von Herrath},
  booktitle={Diabetes},
  year={2017}
}
Type 1 diabetes is characterized by the loss of insulin production caused by β-cell dysfunction and/or destruction. The hypothesis that β-cell loss occurs early during the prediabetic phase has recently been challenged. Here we show, for the first time in situ, that in pancreas sections from autoantibody-positive (Ab+) donors, insulin area and β-cell mass are maintained before disease onset and that production of proinsulin increases. This suggests that β-cell destruction occurs more… CONTINUE READING
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Islet stress, degradation and autoimmunity

  • Diabetes, obesity & metabolism
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